I recently made the switch myself. I do use multiple profiles but I don’t think it’s required for me. I was curious to see how it all works. I may end up switching to a work profile instead. I have google play on my main profile mostly for notifications for WhatsApp etc. A banking profile so that banking details are isolated, and anoyher profile for apps I need that I don’t use often and prefer to not have in my main. In a lot of videos its advsed to not use profiles to begin with as I causes a lot of friction and that makes adoption harder. You can always begin using profiles later on.
I am not logged into GPS and it only has network permissions. I connect via NextDNS and there is so little background traffic in thw logs, it’s a refreshing sight.
I have yet to find anything I could do on iOS that i can’t on Graphene. I install most apps via obtainium and the other few that I can’t via aurora store. I use OSS apps whenever possible.
Librewolf on desktop and ironfox on mobile. The prior for over a year and the latter a few months. Occasionally need to use something else on desktop that needs webgl or similar. I don’t want to change librewolf setting so I use something else. Usually a work related thing anyway